Lenalidomide-4-aminomethyl

Lenalidomide-4-aminomethyl is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-4-aminomethyl can be connected to the ligand for protein by a linker to form PROTAC[1].

Product Specifications

CAS Number

[790652-68-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lenalidomide-4-aminomethyl.html

Solubility

10 mM in DMSO

Smiles

O=C(C(N(CC1=C2C=CC=C1CN)C2=O)CC3)NC3=O

Molecular Formula

C14H15N3O3

Molecular Weight

273.29

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.