Thalidomide-NH-amido-PEG3-C2-NH2

Thalidomide-NH-amido-PEG3-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

[2983036-98-0]

UNSPSC

12352005

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-nh-amido-peg3-c2-nh2.html

Solubility

10 mM in DMSO

Smiles

O=C(C(CC1)N2C(C3=CC=CC(NCC(NCCOCCOCCOCCN)=O)=C3C2=O)=O)NC1=O

Molecular Formula

C23H31N5O8

Molecular Weight

505.52

References & Citations

[1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.