SW02
SW02 is a potent activator of ATPase activity of Hsp70, with an EC50 of 150 μM. SW02 leads to accumulation of both total tau and phosphorylated tau (pTau) [1].
Product Specifications
CAS Number
[1010820-68-4]
UNSPSC
12352005
Hazard Statement
H301
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sw02.html
Purity
98.30
Solubility
DMSO : 20 mg/mL (ultrasonic; warming)
Smiles
O=C(OC)CCCN1C(C)=C(C(OCC)=O)C(C2=CC=C(Br)C=C2)NC1=O
Molecular Formula
C19H23BrN2O5
Molecular Weight
439.30
Precautions
H301
References & Citations
[1]Jinwal UK, et al. Chemical manipulation of hsp70 ATPase activity regulates tau stability. J Neurosci. 2009 Sep 30;29 (39) :12079-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70
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