PC DBCO-PEG4-NHS ester
PC DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PC DBCO-PEG4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Product Specifications
CAS Number
[2055025-02-8]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pc-dbco-peg4-nhs-ester.html
Purity
96.85
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
[O-][N+](C(C(C(OC(ON1C(CCC1=O)=O)=O)C)=C2)=CC(OCCCC(NCCOCCOCCOCCOCCC(NCCC(N3CC4=C(C=CC=C4)C#CC5=C3C=CC=C5)=O)=O)=O)=C2OC)=O
Molecular Formula
C47H55N5O16
Molecular Weight
945.96
Precautions
H302, H315, H319, H335
References & Citations
[1]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-1014.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Available Sizes
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