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Poly (deoxyadenylic-thymidylic) acid (sodium)

Polydeoxyadenylic-thymidylic acid (Poly (dA:dT) ) sodium is a synthetic DNA polymer. Poly (dA:dT) sodium can be used to determine the activity of bound and free ribonucleic acid polymerase. Poly (dA:dT) sodium is recognized by multiple PRRs (cytosolic DNA sensors (CDS), including cGAS, AIM2, DAI, DDX41, IFI16, and LRRFIP1), and triggers the production of type I interferons. Poly (dA:dT) sodium can be used for the research of cancer and virus infection[1].

Product Specifications

CAS Number

86828-69-5

Product Name Alternative

Poly (dA:dT) sodium

UNSPSC

12352200

Target

AIM2; Cyclic GMP-AMP Synthase

Type

Biochemical Assay Reagents

Related Pathways

Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/poly-deoxyadenylic-thymidylic-acid-sodium.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=O)N(C=C1C)[C@](C[C@@H]2O)([H])O[C@@H]2CO[P](O)(O)=O.NC3=C4C(N([C@](C[C@@H]5O)([H])O[C@@H]5CO[P](O)(O)=O)C=N4)=NC=N3.[Na].[x].[x]

Molecular Formula

(C10H15N2O8P.C10H14N5O6P) x.xNa

References & Citations

[1]Graham EM, et al. Effect of gestational age and hypoxia on activity of ribonucleic acid polymerase in fetal guinea pig brain. Am J Obstet Gynecol. 2001 Mar;184 (4) :736-42.|[2]Zhang Z, Yuan B, Bao M, Lu N, Kim T, Liu YJ. The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells [published correction appears in Nat Immunol. 2012 Feb;13 (2) :196]. Nat Immunol. 2011;12 (10) :959-965. |[3]Wu J, Sun L, Chen X, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013;339 (6121) :826-830.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Biochemical Assay Reagents

Clinical Information

No Development Reported

Frequently Asked Questions

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