What is the catalog number for AST5902?

The catalog number for AST5902 is HY-138627.

What sizes are available for AST5902?

AST5902 is available in the following size(s): 1 Each.

AST5902 is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures AST5902?

AST5902 is manufactured by QuantiMol.

What is the estimated delivery time for AST5902?

Estimated delivery time for AST5902 is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for AST5902?

The safety data sheet for AST5902 is available here: http://file.medchemexpress.com/batch_PDF/HY-138627/.

AST5902

AST5902 is the active metabolite of Firmonertinib (EGFR inhibitor). AST5902 has antineoplastic activity[1][2].

Product Specifications

CAS Number

2412155-74-7

UNSPSC

12352005

Target

Drug Metabolite; EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ast5902.html

Solubility

10 mM in DMSO

Smiles

C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(C)CCNC)=O

Molecular Formula

C27H29F3N8O2

Molecular Weight

554.57

References & Citations

[1]Zhu YT, et al. Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third-generation EGFR kinase inhibitor, and its metabolite AST5902 in healthy volunteers. Invest New Drugs. 2021 Aug;39 (4) :1011-1018.|[2]Liu XY, Guo ZT, Chen ZD, Zhang YF, Zhou JL, Jiang Y, Zhao QY, Diao XX, Zhong DF. Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer. Acta Pharmacol Sin. 2020 Oct;41 (10) :1366-1376.