AST5902

AST5902 is the active metabolite of Firmonertinib (HY-112870) (EGFR inhibitor) . AST5902 has antineoplastic activity[1][2].

Product Specifications

CAS Number

[2412155-74-7]

UNSPSC

12352005

Target

Drug Metabolite; EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ast5902.html

Solubility

10 mM in DMSO

Smiles

C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(C)CCNC)=O

Molecular Formula

C27H29F3N8O2

Molecular Weight

554.57

References & Citations

[1]Zhu YT, et al. Effects of rifampicin on the pharmacokinetics of alflutinib, a selective third-generation EGFR kinase inhibitor, and its metabolite AST5902 in healthy volunteers. Invest New Drugs. 2021 Aug;39 (4) :1011-1018.|[2]Liu XY, Guo ZT, Chen ZD, Zhang YF, Zhou JL, Jiang Y, Zhao QY, Diao XX, Zhong DF. Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer. Acta Pharmacol Sin. 2020 Oct;41 (10) :1366-1376.