GSK789

GSK789, a chemical probe, is an effective, cell-permeable, and highly selective inhibitor of the BET family first bromodomain (BD1), with antitumor and immunomodulatory effects[1]

Product Specifications

CAS Number

[2540591-06-6]

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gsk789.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H]1CN(C)CC[C@H]1NC2=C3NC(C(C)=CC3=C(C4=CC=CO4)C=N2)=O)NC5CCCCC5

Molecular Formula

C26H33N5O3

Molecular Weight

463.57

References & Citations

[1]Watson RJ, et al. GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins. J Med Chem. 2020 Sep 10;63 (17) :9045-9069.