dGTP-13C10 (dilithium)
Product Specifications
UNSPSC Description
dGTP-13C10 (2'-Deoxyguanosine-5'-triphosphate-13C10) dilithium is 13C-labeled dGTP (HY-138616). dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.
Target Antigen
DNA/RNA Synthesis; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog
Type
Isotope-Labeled Compounds
Related Pathways
Cell Cycle/DNA Damage;Others
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/dgtp-13c10-dilithium.html
Solubility
10 mM in DMSO
Smiles
O=P(O)(O[Li])OP(OP(O[13CH2][13C@H]1O[13C@@H](N2[13C](N=[13C](N)N[13C]3=O)=[13C]3N=[13CH]2)[13CH2][13C@@H]1O)(O)=O)(O[Li])=O
Molecular Weight
528.97
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202(1):e00567-19. Published 2019 Dec 6.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-138616S3/dGTP-13C10-dilithium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-138616S3/
Clinical Information
No Development Reported
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