DGTP-13C10 (dilithium)

DGTP-13C10 (2'-Deoxyguanosine-5'-triphosphate-13C10) dilithium is 13C-labeled dGTP (HY-138616) . dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

Product Specifications

Product Name Alternative

2'-Deoxyguanosine-5'-triphosphate-13C10 (dilithium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/dgtp-13c10-dilithium.html

Concentration

100 mM in 18.91 μL Tris HCl/H2O buffer pH=7.5

Purity

98.8

Solubility

10 mM in DMSO

Smiles

O=P(O)(O[Li])OP(OP(O[13CH2][13C@H]1O[13C@@H](N2[13C](N=[13C](N)N[13C]3=O)=[13C]3N=[13CH]2)[13CH2][13C@@H]1O)(O)=O)(O[Li])=O

Molecular Formula

13C10H14Li2N5O13P3

Molecular Weight

528.97

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202 (1) :e00567-19. Published 2019 Dec 6.