DGTP-15N5 (dilithium)

DGTP-15N5 (2'-Deoxyguanosine-5'-triphosphate-15N5) dilithium is 15N labeled dGTP (HY-138616) . dGTP (2'-Deoxyguanosine-5'-triphosphate), a guanosine nucleotide, can be used in deoxyribonucleic acid synthesis. Guanosine nucleotides (GDP, GTP, dGDP, and dGTP) are highly susceptible to oxidative damage to 8-oxo-GDP (8-O-GDP), 8-O-dGTP, 8-O-GTP, and 8-O-dGTP.

Product Specifications

CAS Number

[95648-75-2]

Product Name Alternative

2'-Deoxyguanosine-5'-triphosphate-15N5 (dilithium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; Isotope-Labeled Compounds; Nucleoside Antimetabolite/Analog

Type

Isotope-Labeled Compounds

Related Pathways

Cell Cycle/DNA Damage; Others

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/dgtp-15n5-dilithium.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1C[C@H]([15N]2C([15N]=C([15NH2])[15NH]C3=O)=C3[15N]=C2)O[C@@H]1COP(OP(OP(O[Li])(O[Li])=O)(O)=O)(O)=O

Molecular Formula

C10H14Li2 15N5O13P3

Molecular Weight

524.01

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kapoor I, et al. Nucleoside Diphosphate Kinase Escalates A-to-C Mutations in MutT-Deficient Strains of Escherichia coli. J Bacteriol. 2019;202 (1) :e00567-19. Published 2019 Dec 6.