PLX647 (dihydrochloride)
PLX647 dihydrochloride is an orally active, highly specific dual FMS and KIT kinase inhibitor, with IC50s of 28 and 16 nM, reapectively. PLX647 dihydrochloride shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1 μM except FLT3 and KDR (IC50s=91 and 130 nM, respectively) [1].
Product Specifications
CAS Number
1779796-38-1
UNSPSC
12352005
Target
C-Fms; c-Kit
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/plx647-dihydrochloride.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=CC=C(CNC2=CC=C(CC3=CNC4=NC=CC=C43)C=N2)C=C1.Cl.Cl
Molecular Formula
C21H19Cl2F3N4
Molecular Weight
455.30
References & Citations
[1]Zhang C, et al. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc Natl Acad Sci U S A. 2013 Apr 2;110 (14) :5689-94.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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