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PLX647 (dihydrochloride)

PLX647 dihydrochloride is an orally active, highly specific dual FMS and KIT kinase inhibitor, with IC50s of 28 and 16 nM, reapectively. PLX647 dihydrochloride shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1 μM except FLT3 and KDR (IC50s=91 and 130 nM, respectively) [1].

Product Specifications

CAS Number

1779796-38-1

UNSPSC

12352005

Target

C-Fms; c-Kit

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/plx647-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

FC(F)(F)C1=CC=C(CNC2=CC=C(CC3=CNC4=NC=CC=C43)C=N2)C=C1.Cl.Cl

Molecular Formula

C21H19Cl2F3N4

Molecular Weight

455.30

References & Citations

[1]Zhang C, et al. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc Natl Acad Sci U S A. 2013 Apr 2;110 (14) :5689-94.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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