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Endo-BCN-PEG12-NH2 (hydrochloride)

Endo-BCN-PEG12-NH2 hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. endo-BCN-PEG12-NH2 (hydrochloride) is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/endo-bcn-peg12-nh2-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

[H][C@@]12[C@@]([C@H]2COC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN)=O)([H])CCC#CCC1.Cl

Molecular Formula

C35H65ClN2O13

Molecular Weight

757.35

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Frequently Asked Questions

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