Azido-PEG6-THP

Azido-PEG6-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG6-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

UNSPSC

12352005

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/azido-peg6-thp.html

Solubility

10 mM in DMSO

Smiles

[N-]=[N+]=NCCOCCOCCOCCOCCOCCOC1CCCCO1

Molecular Formula

C17H33N3O7

Molecular Weight

391.46

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562