N-trifluoroacetyl-β-alanyl chloride
N-trifluoroacetyl-β-alanyl chloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[87639-76-7]
UNSPSC
12352203
Hazard Statement
H301-H311-H314-H331
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-trifluoroacetyl-β-alanyl-chloride.html
Solubility
10 mM in DMSO
Smiles
O=C(Cl)CCNC(C(F)(F)F)=O
Molecular Formula
C5H5ClF3NO2
Molecular Weight
203.55
Precautions
P260-P264-P270-P271-P280-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P403+P233-P405-P501
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
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