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N-trifluoroacetyl-β-alanyl chloride

N-trifluoroacetyl-β-alanyl chloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

87639-76-7

UNSPSC

12352203

Hazard Statement

H301-H311-H314-H331

Target

ADC Linker

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-trifluoroacetyl-β-alanyl-chloride.html

Solubility

10 mM in DMSO

Smiles

O=C(Cl)CCNC(C(F)(F)F)=O

Molecular Formula

C5H5ClF3NO2

Molecular Weight

203.55

Precautions

P260-P264-P270-P271-P280-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P403+P233-P405-P501

References & Citations

[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.

Shipping Conditions

Room temperature

Scientific Category

ADC Related

Clinical Information

No Development Reported

Isoform

Cleavable Linker

Frequently Asked Questions

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