7ß,27-Dihydroxycholesterol
Product Specifications
UNSPSC Description
7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1[1].
Target Antigen
ROR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/7-27-dihydroxycholesterol.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
C[C@@H](CO)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Weight
418.65
References & Citations
[1]Soroosh P, et al. Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12163-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-138115/7-27-Dihydroxycholesterol-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-138115/7-27-Dihydroxycholesterol-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
240129-43-5
Curated Selection
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