7ß,27-Dihydroxycholesterol

7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM) . 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4+ Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1[1].

Product Specifications

CAS Number

[240129-43-5]

Product Name Alternative

7β, 27-OHC

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

ROR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/7-27-dihydroxycholesterol.html

Purity

99.5

Solubility

10 mM in DMSO|Ethanol : ≥ 20mg/mL

Smiles

C[C@@H](CO)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Molecular Formula

C27H46O3

Molecular Weight

418.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Soroosh P, et al. Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation. Proc Natl Acad Sci U S A. 2014 Aug 19;111 (33) :12163-8.