Z-LLF-CHO
Z-LLF-CHO (Z-Leu-Leu-Phe-CHO) is a potent inhibitor of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex (Ki = 460 nM) . Z-LLF-CHO is also a NF-κB nuclear translocation inhibitor[1][2].
Product Specifications
CAS Number
133429-58-0
Product Name Alternative
Z-Leu-Leu-Phe-CHO
UNSPSC
12352209
Target
Proteasome
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z-llf-cho.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C=O)CC1=CC=CC=C1)[C@H](CC(C)C)NC([C@H](CC(C)C)NC(OCC2=CC=CC=C2)=O)=O
Molecular Formula
C29H39N3O5
Molecular Weight
509.64
References & Citations
[1]Orlowski M, et al. Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids. Biochemistry. 1993 Feb 16;32 (6) :1563-72.|[2]Ding L, et al. Epstein-Barr virus encoded latent membrane protein 1 modulates nuclear translocation of telomerase reverse transcriptase protein by activating nuclear factor-kappaB p65 in human nasopharyngeal carcinoma cells. Int J Biochem Cell Biol. 2005 Sep;37 (9) :1881-9.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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