8α-Tigloyloxyhirsutinolide 13-O-acetate
8α-Tigloyloxyhirsutinolide 13-O-acetate (8αTGH) is a potent and orally active STAT3 inhibitor. 8α-Tigloyloxyhirsutinolide 13-O-acetate induces early oxidative stress and pyroptosis, and late DNA damage, cell cycle arrest, apoptosis in the TNBC cells. 8α-Tigloyloxyhirsutinolide 13-O-acetate suppresses tumor cell growth in vitro and tumor growth in vivo[1][2].
Product Specifications
CAS Number
[83182-58-5]
Product Name Alternative
8αTGH
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; c-Myc; Pyroptosis; Reactive Oxygen Species (ROS) ; STAT; TrxR
Type
Natural Products
Related Pathways
Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/8α-tigloyloxyhirsutinolide-13-o-acetate.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
O=C(/C(C)=C/C)O[C@@H](C[C@H]1C)C(/C(OC2=O)=C\[C@](O[C@]13O)(CC3)C)=C2COC(C)=O
Molecular Formula
C22H28O8
Molecular Weight
420.45
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Bcl-2; Bcl-xL; Mcl-1; STAT3
Available Sizes
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