Penehyclidine (hydrochloride)
Product Specifications
UNSPSC Description
Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1].
Target Antigen
mAChR; NF-κB
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling;NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/penehyclidine-hydrochloride.html
Purity
99.2
Solubility
H2O : 2 mg/mL (ultrasonic;warming)
Smiles
OC(C1CCCC1)(COC2CN3CCC2CC3)C4=CC=CC=C4.[H]Cl
Molecular Weight
351.91
References & Citations
[1]Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137976/Penehyclidine-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137976/Penehyclidine-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
151937-76-7
Curated Selection
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