Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Penehyclidine (hydrochloride)

Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1].

Product Specifications

CAS Number

151937-76-7

Product Name Alternative

Penequinine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Akt; Apoptosis; Autophagy; ERK; GSK-3; mAChR; NF-κB

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/penehyclidine-hydrochloride.html

Purity

99.2

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC(C1CCCC1)(COC2CN3CCC2CC3)C4=CC=CC=C4.[H]Cl

Molecular Formula

C20H30ClNO2

Molecular Weight

351.91

Precautions

H302, H315, H319

References & Citations

[1]Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885.|[2]Wang X, et al., Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute respiratory distress syndrome in cells via regulating autophagy‑related pathway. Mol Med Rep. 2021 Feb;23 (2) :100.|[3]Zi C, et al., Penehyclidine hydrochloride protects against anoxia/reoxygenation injury in cardiomyocytes through ATP-sensitive potassium channels, and the Akt/GSK-3β and Akt/mTOR signaling pathways. Cell Biol Int. 2020 Jun;44 (6) :1353-1362.|[4]Sun X, et al., A Selective M1 and M3 Receptor Antagonist, Penehyclidine Hydrochloride, Exerts Antidepressant-Like Effect in Mice. Neurochem Res. 2019 Dec;44 (12) :2723-2732.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

MAChR1; mAChR3; NF-κB

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

CLDN11 Antibody
A76866-100UL 100 µL

CLDN11 Antibody

Sign In for Pricing
View Details
C16orf67 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)
LV810113 1.0 µg DNA

C16orf67 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

Sign In for Pricing
View Details
CHIT1 Rabbit Polyclonal Antibody
orb555969 100 µL

CHIT1 Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
RNF128 Antibody Blocking peptide
orb1451689 500 µg

RNF128 Antibody Blocking peptide

Sign In for Pricing
View Details
Mouse Monoclonal CENPQ Antibody (OTI1C5) [CoraFluor 1]
NBP2-71991CL1 0.1 mL

Mouse Monoclonal CENPQ Antibody (OTI1C5) [CoraFluor 1]

Sign In for Pricing
View Details
LTBP2 (Latent-transforming growth factor beta-binding protein 2) BioAssayTM ELISA Kit (Human) discontinued
357142-01 48 Tests

LTBP2 (Latent-transforming growth factor beta-binding protein 2) BioAssayTM ELISA Kit (Human) discontinued

Sign In for Pricing
View Details