Penehyclidine (hydrochloride)

Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation[1].

Product Specifications

CAS Number

[151937-76-7]

Product Name Alternative

Penequinine (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Akt; Apoptosis; Autophagy; ERK; GSK-3; mAChR; NF-κB

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; GPCR/G Protein; MAPK/ERK Pathway; Neuronal Signaling; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/penehyclidine-hydrochloride.html

Purity

99.2

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC(C1CCCC1)(COC2CN3CCC2CC3)C4=CC=CC=C4.[H]Cl

Molecular Formula

C20H30ClNO2

Molecular Weight

351.91

Precautions

H302, H315, H319

References & Citations

[1]Zhi-Yuan Chen, et al. The Mechanism of Penehyclidine Hydrochloride and Its Effect on the Inflammatory Response of Lung Tissue in Rats with Chronic Obstructive Pulmonary Disease During Mechanical Ventilation. Int J Chron Obstruct Pulmon Dis. 2021 Mar 31;16:877-885.|[2]Wang X, et al., Penehyclidine hydrochloride alleviates lipopolysaccharide‑induced acute respiratory distress syndrome in cells via regulating autophagy‑related pathway. Mol Med Rep. 2021 Feb;23 (2) :100.|[3]Zi C, et al., Penehyclidine hydrochloride protects against anoxia/reoxygenation injury in cardiomyocytes through ATP-sensitive potassium channels, and the Akt/GSK-3β and Akt/mTOR signaling pathways. Cell Biol Int. 2020 Jun;44 (6) :1353-1362.|[4]Sun X, et al., A Selective M1 and M3 Receptor Antagonist, Penehyclidine Hydrochloride, Exerts Antidepressant-Like Effect in Mice. Neurochem Res. 2019 Dec;44 (12) :2723-2732.