Oxidized ATP (trisodium salt)
Product Specifications
UNSPSC Description
Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP)-induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis[1][2].
Target Antigen
NOD-like Receptor (NLR); P2X Receptor
Type
Reference compound
Related Pathways
Immunology/Inflammation;Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/oxidized-atp-trisodium-salt.html
Purity
98.0
Solubility
H2O : 50 mg/mL (ultrasonic;warming)
Smiles
O=P(O)(O[Na])OP(OP(OC[C@H](C=O)O[C@@H](N1C2=NC=NC(N)=C2N=C1)C=O)(O[Na])=O)(O[Na])=O
Molecular Weight
571.11
References & Citations
[1]Bian F, et al. CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells. Front Pharmacol. 2019 Jan 30;10:40. |[2]Zhao R, et al. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU). PLoS One. 2016 May 19;11(5):e0155953.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137888A/Oxidized-ATP-trisodium-salt-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137888A/Oxidized-ATP-trisodium-salt-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
71997-40-5
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