Oxidized ATP (trisodium salt)

Oxidized ATP (oATP) trisodium salt is a broad-spectrum P2 receptor inhibitor. Oxidized ATP trisodium salt irreversibly antagonizes P2X7R activation. Oxidized ATP trisodium salt inhibits c-reactive protein (CRP) -induced NLRP3 inflammasome activation. Oxidized ATP trisodium salt can be used for research of atherosclerosis[1][2].

Product Specifications

CAS Number

[71997-40-5]

Product Name Alternative

OATP (trisodium salt)

UNSPSC

12352005

Target

NOD-like Receptor (NLR) ; P2X Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/oxidized-atp-trisodium-salt.html

Purity

98.0

Solubility

H2O : 50 mg/mL (ultrasonic; warming)

Smiles

O=P(O)(O[Na])OP(OP(OC[C@H](C=O)O[C@@H](N1C2=NC=NC(N)=C2N=C1)C=O)(O[Na])=O)(O[Na])=O

Molecular Formula

C10H11N5Na3O13P3

Molecular Weight

571.11

References & Citations

[1]Bian F, et al. CRP-Induced NLRP3 Inflammasome Activation Increases LDL Transcytosis Across Endothelial Cells. Front Pharmacol. 2019 Jan 30;10:40. |[2]Zhao R, et al. Blockade of Extracellular ATP Effect by Oxidized ATP Effectively Mitigated Induced Mouse Experimental Autoimmune Uveitis (EAU) . PLoS One. 2016 May 19;11 (5) :e0155953.