DdCTP (trilithium)

DdCTP trilithium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddCTP trilithium is a nucleoside analog that targets the reverse trsanscriptase of human immunodeficiency virus (HIV) . ddCTP trilithium can be used for AIDS research[1][2].

Product Specifications

CAS Number

[93939-77-6]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

DNA/RNA Synthesis; HIV Protease

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ddctp-trilithium.html

Solubility

10 mM in DMSO

Smiles

O=[P](O[P](O[P](O)(O[Li])=O)(O[Li])=O)(O[Li])OC[C@@H]1CC[C@H](N2C(N=C(N)C=C2)=O)O1

Molecular Formula

C9H13Li3N3O12P3

Molecular Weight

468.96

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Z G Chidgeavadze, et al. 3'-Fluoro-2',3'-dideoxyribonucleoside 5'-triphosphates: terminators of DNA synthesis. FEBS Lett. 1985 Apr 22;183 (2) :275-8.|[2]Pelletier H, et al. Structures of ternary complexes of rat DNA polymerase beta, a DNA template-primer, and ddCTP. Science. 1994 Jun 24;264 (5167) :1891-903.