Topotecan (hydrochloride hydrate)

Topotecan hydrochloride hydrate is an orally active and potent Topoisomerase I inhibitor. Topotecan hydrochloride hydrate induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan hydrochloride hydrate shows anticancer activity[1].

Product Specifications

CAS Number

[1044663-62-8]

Product Name Alternative

SKF 104864A (hydrochloride hydrate) ; NSC 609669 (hydrochloride hydrate)

UNSPSC

12352005

Target

Apoptosis; Autophagy; Topoisomerase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/topotecan-hydrochloride-hydrate.html

Solubility

10 mM in DMSO

Smiles

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=CC5=C(CN(C)C)C(O)=CC=C5N=C4C3=C2)=O.Cl.O

Molecular Formula

C23H26ClN3O6

Molecular Weight

475.92

References & Citations

[1]Zhang FL, et al. PLoS One. 2013 Nov 26;8 (11) :e81815.Topoisomerase I inhibitors, Shikonin and Topotecan, inhibit growth and induce apoptosis of glioma cells andglioma stem cells.|[2]Kumar S, et al. Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res. 2011 Sep 1;17 (17) :5656-67.