Purine riboside triphosphate
Purine riboside-5'-O-triphosphate, an active metabolite of Nebularine , acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate also inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM[1][2][3].
Product Specifications
CAS Number
23197-96-8
Product Name Alternative
PTP
UNSPSC
12352005
Target
CaMK; DNA/RNA Synthesis; Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/purine-riboside-triphosphate.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(OP(OP(O)(O)=O)(O)=O)(O)=O)N2C3=NC=NC=C3N=C2
Molecular Formula
C10H15N4O13P3
Molecular Weight
492.17
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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