Rp-dGTPαS
Rp-dGTPαS is the nucleotide substrate of SAMHD1 and is one of the enantiomers of the dNTPαS nucleotide. SAMHD1 is an essential regulator of cellular dNTPs that limits virus (HIV-1, etc.) replication in the CD4+ myeloid lineage and resting T cells. The SAMHD1 tetrameric complex catalyzes the hydrolysis of Rp-dGTPαS into 2'-deoxynucleosides and triphosphates[1].
Product Specifications
CAS Number
80902-29-0
UNSPSC
12352005
Target
HIV
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rp-dgtpαs.html
Solubility
10 mM in DMSO
Smiles
OP(OP(O[P@@](OC[C@@H]1[C@@H](O)C[C@H](N(C=N2)C(NC(N)=N3)=C2C3=O)O1)(S)=O)(O)=O)(O)=O
Molecular Formula
C10H16N5O12P3S
Molecular Weight
523.25
References & Citations
[1]Morris ER, et al. Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of Rp- and Sp-dNTPαS Diastereomers. Biochemistry. 2021 Jun 1;60 (21) :1682-1698.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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