Tacrolimus-13C, d2

Tacrolimus-13C, d2 is a 13C-labeled and deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties[1].

Product Specifications

CAS Number

[1356841-89-8]

Product Name Alternative

FK506-13C, d2; Fujimycin-13C, d2; FR900506-13C, d2

UNSPSC

12352005

Hazard Statement

H301

Target

Antibiotic; Autophagy; Bacterial; FKBP; Phosphatase

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Cancer; Infection; Inflammation/Immunology

Purity

98.36

Solubility

DMF : ≥ 30mg/mL|DMSO : ≥ 20mg/mL|Ethanol : ≥ 30mg/mL

Smiles

O=C(O[C@@H]([C@@H]([C@H](CC1=O)O)C)/C(C)=C/[C@H]2C[C@H]([C@@H](CC2)O)OC)[C@]3([H])CCCCN3C(C([C@]4([C@@H](C[C@@H]([C@@]([H])([C@H](C[C@H](C/C(C)=C/[C@H]1C/C=[13C]([2H])\[2H])C)OC)O4)OC)C)O)=O)=O

Molecular Formula

C43 13CH67D2NO12

Molecular Weight

807.02

Precautions

H301

References & Citations

[1]Thomson AW, et al. Mode of action of Tacrolimus (FK506) : molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17 (6) :584-91.; Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcri|[2]Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism. J Inherit Metab Dis. 2016 Nov;39 (6) :877-886.|[3]A W Thomson, et al. Mode of action of Tacrolimus (FK506) : molecular and cellular mechanisms. Ther Drug Monit. 1995 Dec;17 (6) :584-91.; Vogel KR