7-Hydroxyquetiapine

7-Hydroxyquetiapine (ICI 214227) is the major active metabolite of antipsychotic medicine Quetiapine[1].

Product Specifications

CAS Number

[139079-39-3]

Product Name Alternative

ICI 214227

UNSPSC

12352005

Hazard Statement

H225-H301+H311+H331-H370

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/7-hydroxyquetiapine.html

Solubility

10 mM in DMSO

Smiles

OC1=CC=C2C(SC3=CC=CC=C3C(N4CCN(CCOCCO)CC4)=N2)=C1

Molecular Formula

C21H25N3O3S

Molecular Weight

399.51

Precautions

P210-P233-P240-P241-P242-P243-P260-P261-P264-P270-P271-P280-P302+P352-P303+P361+P353-P304+P340-P308+P311-P330-P361+P364-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Bakken GV, et al. Metabolism of quetiapine by CYP3A4 and CYP3A5 in presence or absence of cytochrome B5. Drug Metab Dispos. 2009 Feb;37 (2) :254-8.