Zidovudine O-β-D-glucuronide

Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the major metabolite of Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection[1][2].

Product Specifications

CAS Number

[117675-21-5]

Product Name Alternative

3'-Azido-3'-deoxythymidine β-D-glucuronide

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Drug Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/zidovudine-o-β-d-glucuronide.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C=C(C(N1)=O)C)[C@@H]2O[C@@H]([C@H](C2)N=[N+]=[N-])CO[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O

Molecular Formula

C16H21N5O10

Molecular Weight

443.37

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

References & Citations

[1]Fayz S, et, al. Zidovudine azido-reductase in human liver microsomes: activation by ethacrynic acid, dipyridamole, and indomethacin and inhibition by human immunodeficiency virus protease inhibitors. Antimicrob Agents Chemother. 1998 Jul;42 (7) :1654-8.|[2]Bélanger AS, et, al. Glucuronidation of the antiretroviral drug efavirenz by UGT2B7 and an in vitro investigation of drug-drug interaction with zidovudine. Drug Metab Dispos. 2009 Sep;37 (9) :1793-6.