LC-2 epimer
LC-2 epimer is a differential isomer of LC-2. LC-2 is a mutation-selective PROTAC depressant for KRAS and contains a ligand for the von Hippel Lindau E3 ligase linked to the KRAS inhibitor MRTX849[1].
Product Specifications
CAS Number
[2502156-12-7]
UNSPSC
12352005
Target
PROTACs; Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lc-2-epimer.html
Solubility
10 mM in DMSO
Smiles
O=C(N1[C@@H](C[C@@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCOCCCN(CCC4)[C@@H]4COC5=NC(N6C[C@@H](N(CC6)C(C(F)=C)=O)CC#N)=C7C(CN(C8=CC=CC9=C8C(Cl)=CC=C9)CC7)=N5)=O
Molecular Formula
C59H71ClFN11O7S
Molecular Weight
1132.78
References & Citations
[1]Bond MJ, et al. Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs. ACS Cent Sci. 2020 Aug 26;6 (8) :1367-1375.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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