ML267
ML267 a potent Sfp phosphopantetheinyl transferase (PPTases) inhibitor with an IC50 of 0.29 μM. ML267 also inhibits AcpS-PPTase with an IC50 of 8.1 μM. ML267 possesses specific Gram-positive-targeted bactericidal activities[1].
Product Specifications
CAS Number
1542213-67-1
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ml267.html
Solubility
10 mM in DMSO
Smiles
S=C(N1CCN(C2=NC=C(C(F)(F)F)C=C2Cl)CC1)NC3=NC=CC(OC)=C3.O=C(O)C(F)(F)F
Molecular Formula
C19H18ClF6N5O3S
Molecular Weight
545.89
References & Citations
[1]Foley TL, et al. J. 4- (3-Chloro-5- (trifluoromethyl) pyridin-2-yl) -N- (4-methoxypyridin-2-yl) piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth. J Med Chem. 2014 Feb 13;57 (3) :1063-78.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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