Sivopixant
Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC50=4.2 nM; P2X2/3 IC50=1100 nM) . Sivopixant shows strong analgesic effect[1].
Product Specifications
CAS Number
[2414285-40-6]
Product Name Alternative
S-600918
UNSPSC
12352005
Target
P2X Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sivopixant.html
Purity
99.90
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N(C1=O)C[C@H](C)C(O)=O)N/C(N1CC2=CC=C(C=C2)Cl)=N\C3=CC=C(C=C3)OC4=CC=CC=N4
Molecular Formula
C25H22ClN5O5
Molecular Weight
507.93
References & Citations
[1]Kai H, et al. Discovery of clinical candidate Sivopixant (S-600918) : Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists [published online ahead of print, 2021 Sep 26]. Bioorg Med Chem Lett. 2021;52:128384.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
P2X3 Receptor
Curated Selection
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