Procarbazine

Procarbazine is an orally active alkylating agent, with anticancer activity. Procarbazine can be used in Hodgkin's disease research[1][2].

Product Specifications

CAS Number

[671-16-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335-H351-H361

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/procarbazine.html

Solubility

10 mM in DMSO

Smiles

O=C(NC(C)C)C1=CC=C(CNNC)C=C1

Molecular Formula

C12H19N3O

Molecular Weight

221.30

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]J M Erikson, et al. Cytotoxicity and DNA damage caused by the azoxy metabolites of procarbazine in L1210 tumor cells. Cancer Res. 1989 Jan 1;49 (1) :127-33.|[2]T Suzuki, et al. Procarbazine genotoxicity in the MutaMouse; strong clastogenicity and organ-specific induction of lacZ mutations. Mutat Res. 1999 Aug 18;444 (2) :269-81.