S- (2,4-Dinitrophenyl) glutathione

S- (2,4-Dinitrophenyl) glutathione is a substrate for glutathione-S-transferase. (2,4-Dinitrophenyl) glutathione can be used as an irreversible glutathione reductase inhibitor with an Ki value of 30 µM[1][2].

Product Specifications

CAS Number

[26289-39-4]

UNSPSC

12352209

Target

Endogenous Metabolite

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/s-2-4-dinitrophenyl-glutathione.html

Purity

99.89

Solubility

10 mM in DMSO

Smiles

OC([C@@H](N)CCC(N[C@H](C(NCC(O)=O)=O)CSC1=C(C=C(C=C1)[N+]([O-])=O)[N+]([O-])=O)=O)=O

Molecular Formula

C16H19N5O10S

Molecular Weight

473.41

References & Citations

[1]Yokooji T, et al. Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells. J Pharm Pharmacol. 2007 Apr;59 (4) :513-20.|[2]Bilzer M, et al. Interaction of a glutathione S-conjugate with glutathione reductase. Kinetic and X-ray crystallographic studies. Eur J Biochem. 1984 Jan 16;138 (2) :373-8.