TML-6-d3
Product Specifications
UNSPSC Description
TML-6-d3 is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ). TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-
Target Antigen
Amyloid-β; Isotope-Labeled Compounds; Keap1-Nrf2; mTOR; NF-κB
Type
Isotope-Labeled Compounds
Related Pathways
Neuronal Signaling;NF-κB;Others;PI3K/Akt/mTOR
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C(C=C1)/C=C/C(C(C([2H])([2H])[2H])(C(/C=C/C2=CC=C(C(OC)=C2)OC)=O)CC(N(CC)CC)=O)=O)OC
Molecular Weight
526.64
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Ih-Jen Su, et al. A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model. Int J Mol Sci. 2020 Jul 30;21(15):5459.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
2673270-28-3
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