TML-6-d3

TML-6-d3 is the deuterium labeled TML-6. TML-6, an orally active curcumin derivative, inhibits the synthesis of the β-amyloid precursor protein and β-amyloid (Aβ) . TML-6 can upregulate Apo E, suppress NF-κB and mTOR, and increase the activity of the anti-

Product Specifications

CAS Number

[2673270-28-3]

UNSPSC

12352005

Target

Amyloid-β; Isotope-Labeled Compounds; Keap1-Nrf2; mTOR; NF-κB

Type

Isotope-Labeled Compounds

Related Pathways

Neuronal Signaling; NF-κB; Others; PI3K/Akt/mTOR

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Solubility

10 mM in DMSO

Smiles

COC1=C(C=C(C=C1)/C=C/C(C(C([2H])([2H])[2H])(C(/C=C/C2=CC=C(C(OC)=C2)OC)=O)CC(N(CC)CC)=O)=O)OC

Molecular Formula

C30H34D3NO7

Molecular Weight

526.64

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Ih-Jen Su, et al. A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and β-Amyloid Accumulation in a Mouse Model. Int J Mol Sci. 2020 Jul 30;21 (15) :5459.