Cholest-5-ene-3ß,22 (S) -diol

Cholest-5-ene-3ß,22 (S) -diol ((22S) -Hydroxycholesterol) is an orally active oxysterol with no significant cytotoxic, oxidative, or inflammatory effects on human prokaryotic leukemia cells. Cholest-5-ene-3ß,22 (S) -diol inhibits weight gain and increased serum triacylglycerol (TAG) levels in rat models[1][2].

Product Specifications

CAS Number

[22348-64-7]

Product Name Alternative

(22S) -Hydroxycholesterol

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

ATP-binding cassette (ABC) transporters; LXR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cholest-5-ene-3-22-s-diol.html

Purity

98.6

Solubility

10 mM in DMSO

Smiles

C[C@]12[C@](CC[C@]1([H])[C@H](C)[C@@H](O)CCC(C)C)([H])[C@@](CC=C3C[C@H]4O)([H])[C@@](CC2)([H])[C@]3(CC4)C

Molecular Formula

C27H46O2

Molecular Weight

402.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Lemaire-Ewing S, et al. Comparison of the cytotoxic, pro-oxidant and pro-inflammatory characteristics of different oxysterols. Cell Biol Toxicol. 2005 Mar;21 (2) :97-114. |[2]Tranheim Kase E, et al. Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol. Lipids. 2012 May;47 (5) :483-93.