(R) -Plevitrexed
(R) -Plevitrexed ((R) -ZD 9331; (R) -BGC9331) is a less active enantiomer of Plevitrexed[1]. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor[2]. (R) -Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
153537-74-7
Product Name Alternative
(R) -ZD 9331; (R) -BGC9331
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-plevitrexed.html
Solubility
10 mM in DMSO
Smiles
O=C(NC(C)=N1)C2=C1C=C(C)C(CN(C3=CC=C(C(N[C@@H](C(O)=O)CCC4=NNN=N4)=O)C(F)=C3)CC#C)=C2
Molecular Formula
C26H25FN8O4
Molecular Weight
532.53
References & Citations
[1]Tochowicz A, et al. Development and binding mode assessment of N-[4-[2-propyn-1-yl[ (6S) -4,6,7,8-tetrahydro-2- (hydroxymethyl) -4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem. 2013 Jul 11;56 (13) :5446-55.|[2]Marsham PR, et al. Design and synthesis of potent non-polyglutamatable quinazoline antifolatethymidylate synthase inhibitors. J Med Chem. 1999 Sep 23;42 (19) :3809-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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