(R) -Plevitrexed
(R) -Plevitrexed ((R) -ZD 9331; (R) -BGC9331) is a less active enantiomer of Plevitrexed[1]. Plevitrexed is an orally active and potent thymidylate synthase (TS) inhibitor[2]. (R) -Plevitrexed is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
153537-74-7
Product Name Alternative
(R) -ZD 9331; (R) -BGC9331
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-plevitrexed.html
Solubility
10 mM in DMSO
Smiles
O=C(NC(C)=N1)C2=C1C=C(C)C(CN(C3=CC=C(C(N[C@@H](C(O)=O)CCC4=NNN=N4)=O)C(F)=C3)CC#C)=C2
Molecular Formula
C26H25FN8O4
Molecular Weight
532.53
References & Citations
[1]Tochowicz A, et al. Development and binding mode assessment of N-[4-[2-propyn-1-yl[ (6S) -4,6,7,8-tetrahydro-2- (hydroxymethyl) -4-oxo-3H-cyclopenta[g]quinazolin-6-yl]amino]benzoyl]-l-γ-glutamyl-D-glutamic acid (BGC 945), a novel thymidylate synthase inhibitor that targets tumor cells. J Med Chem. 2013 Jul 11;56 (13) :5446-55.|[2]Marsham PR, et al. Design and synthesis of potent non-polyglutamatable quinazoline antifolatethymidylate synthase inhibitors. J Med Chem. 1999 Sep 23;42 (19) :3809-20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TA380097 100 µL
Pancreatic Lipase Related Protein 2 (PNLIPRP2) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details 
TA362736 100 µL
DNA Polymerase beta (POLB) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details 
11400-AAT 200 Tests
Amplite® Colorimetric Acetylcholinesterase Assay Kit
Sign In for Pricing
View Details