Taurolithocholic acid 3-sulfate (disodium)

Taurolithocholic acid 3-sulfate disodium is a GPR39 agonist with EC50s of 71.6 and 69.4 (absence of Zn2+) and 9 and 9.6 μM (presence of Zn2+) in M39-20 and hGPR39-2 cells, respectively. Taurolithocholic acid 3-sulfate disodium stimulates GPR39 receptors to initiate intracellular calcium signaling, independent of Zn2+ binding sites H17 and H19. Taurolithocholic acid 3-sulfate disodium can be used for the research of gallbladder disease[1].

Product Specifications

CAS Number

[64936-83-0]

Product Name Alternative

3-Sulfotaurolithocholic acid (disodium)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

GPR39

Type

Biochemical Assay Reagents

Related Pathways

GPCR/G Protein

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/taurolithocholic-acid-3-sulfate-disodium.html

Purity

99.9

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@H](CCC(NCCS(=O)(O[Na])=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](OS(=O)(O[Na])=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

Molecular Formula

C26H43NNa2O8S2

Molecular Weight

607.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Zi, Zhentao; Xian, Yi; Han, Shangchen; Zhou, Enxing; Wang, Meihuang; Rao, Yi. Use of bile acids and derivatives thereof in preparation of GPR39 agonist. WO2021083336A1.