(S) -UFR2709
(S) -UFR2709 is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S) -UFR2709 decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S) -UFR2709 acts as an anxiolytic agent and can be used for the study of nicotine addiction[1][2].
Product Specifications
CAS Number
[1431628-22-6]
UNSPSC
12352005
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-ufr2709.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC=C1)OC[C@H](CCC2)N2C
Molecular Formula
C13H17NO2
Molecular Weight
219.28
References & Citations
[1]Gabriel Quiroz, et al. UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats. Front Pharmacol. 2019 Dec 3;10:1429.|[2]Franco Viscarra, et al. Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish. Molecules. 2020 Jun 30;25 (13) :2998.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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