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(S) -UFR2709

(S) -UFR2709 is a competitive nAChR antagonist and displays higher affinity for α4β2 nAChRs than for α7 nAChRs. (S) -UFR2709 decreases anxiety and reduces ethanol consumption and ethanol preference in alcohol-preferring rats. (S) -UFR2709 acts as an anxiolytic agent and can be used for the study of nicotine addiction[1][2].

Product Specifications

CAS Number

[1431628-22-6]

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-ufr2709.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC=C1)OC[C@H](CCC2)N2C

Molecular Formula

C13H17NO2

Molecular Weight

219.28

References & Citations

[1]Gabriel Quiroz, et al. UFR2709, a Nicotinic Acetylcholine Receptor Antagonist, Decreases Ethanol Intake in Alcohol-Preferring Rats. Front Pharmacol. 2019 Dec 3;10:1429.|[2]Franco Viscarra, et al. Nicotinic Antagonist UFR2709 Inhibits Nicotine Reward and Decreases Anxiety in Zebrafish. Molecules. 2020 Jun 30;25 (13) :2998.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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