10-Formyl-7,8-dihydrofolic acid
10-Formyl-7,8-dihydrofolic acid is a substrate for mammalian aminoimidazolecarboxamide ribotide transformylase (EC 2.1.2.3) . 10-Formyl-7,8-dihydrofolic acid also is a metabolite of 10-HCO-H4folate[1][2].
Product Specifications
CAS Number
28459-40-7
UNSPSC
12352005
Hazard Statement
H317, H334
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/10-formyl-7-8-dihydrofolic-acid.html
Purity
97.70
Solubility
10 mM in DMSO
Smiles
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2=NC3=C(N=C(N)NC3=O)NC2)C=O)C=C1)=O
Molecular Formula
C20H21N7O7
Molecular Weight
471.42
Precautions
H317, H334
References & Citations
[1]Baggott JE, et al. Iron compounds catalyze the oxidation of 10-formyl-5,6,7,8 tetrahydrofolic acid to 10-formyl-7,8 dihydrofolic acid. J Inorg Biochem. 1998 Sep;71 (3-4) :181-7.|[2]Baggott JE, et al. Metabolism of 10-formyldihydrofolate in humans. Biomed Pharmacother. 2001 Oct;55 (8) :454-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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