10-Formyl-7,8-dihydrofolic acid

10-Formyl-7,8-dihydrofolic acid is a substrate for mammalian aminoimidazolecarboxamide ribotide transformylase (EC 2.1.2.3) . 10-Formyl-7,8-dihydrofolic acid also is a metabolite of 10-HCO-H4folate[1][2].

Product Specifications

CAS Number

[28459-40-7]

UNSPSC

12352005

Hazard Statement

H317, H334

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/10-formyl-7-8-dihydrofolic-acid.html

Purity

97.70

Solubility

10 mM in DMSO

Smiles

O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(N(CC2=NC3=C(N=C(N)NC3=O)NC2)C=O)C=C1)=O

Molecular Formula

C20H21N7O7

Molecular Weight

471.42

Precautions

H317, H334

References & Citations

[1]Baggott JE, et al. Iron compounds catalyze the oxidation of 10-formyl-5,6,7,8 tetrahydrofolic acid to 10-formyl-7,8 dihydrofolic acid. J Inorg Biochem. 1998 Sep;71 (3-4) :181-7.|[2]Baggott JE, et al. Metabolism of 10-formyldihydrofolate in humans. Biomed Pharmacother. 2001 Oct;55 (8) :454-7.