Dimethindene

Dimethindene is a potent, selective histamine H1 antagonist. Dimethindene impairs cutaneous wound healing (WH) . Dimethindene can block K+ currents[1][2].

Product Specifications

CAS Number

[5636-83-9]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Endogenous Metabolite; Histamine Receptor; Potassium Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dimethindene.html

Purity

98.94

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

CC(C1=C(CCN(C)C)CC2=C1C=CC=C2)C3=NC=CC=C3

Molecular Formula

C20H24N2

Molecular Weight

292.42

Precautions

H315, H319, H335

References & Citations

[1]Weller K, et, al. Mast cells are required for normal healing of skin wounds in mice. FASEB J. 2006 Nov;20 (13) :2366-8.|[2]Sakuta H. Inhibition by histamine H1 receptor antagonists of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes. Eur J Pharmacol. 1994 Jan 1;266 (1) :99-102.