AZ-GHS-22
AZ-GHS-22 is a potent, non-CNS penetrant GHS-R1a inverse agonist (IC50=0.77 nM) [1].
Product Specifications
CAS Number
1143020-91-0
UNSPSC
12352005
Hazard Statement
H302+H312+H332-H315-H319-H335
Target
GHSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/az-ghs-22.html
Solubility
10 mM in DMSO
Smiles
O=C(NC(NC1=NC2=CC=C(S(=O)(CCCN3CCN(C)CC3)=O)C=C2S1)=O)C4=CC(N5CCOCC5)=CC=C4Cl
Molecular Formula
C27H33ClN6O5S2
Molecular Weight
621.17
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]McCoull W, et al. Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. J Med Chem. 2014;57 (14) :6128-6140.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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