Nimustine

Nimustine is an alkylating agent, which induces DNA double-strand breaks (DSBs) and inter-strand crosslinks (ICLs), thereby activating the DNA damage response (DDR) signaling pathway. Nimustine activates p38 MAPK/JNK signaling pathway, and exhibits antitumor activity[1][2].

Product Specifications

CAS Number

[42471-28-3]

UNSPSC

12352005

Target

AP-1; Apoptosis; DNA Alkylator/Crosslinker; DNA/RNA Synthesis; JNK; p38 MAPK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nimustine.html

Solubility

10 mM in DMSO

Smiles

O=C(NCC1=CN=C(C)N=C1N)N(CCCl)N=O

Molecular Formula

C9H13ClN6O2

Molecular Weight

272.69

References & Citations

[1]Tomicic MT, et al. Apoptosis induced by temozolomide and nimustine in glioblastoma cells is supported by JNK/c-Jun-mediated induction of the BH3-only protein BIM. Oncotarget. 2015 Oct 20;6 (32) :33755-68.|[2]Shimizu F, et al. Effects of combined treatment with nimustine hydrochloride and radiation on solid FM3A tumor in mice. Jpn J Cancer Res. 1987 Jul;78 (7) :756-62.