2′-Thioadenosine

2'-Thioadenosine (PD157432) is a selective and irreversible inhibitor of ErbB-1 and ErbB-2, with an IC50 of 45 µM for ErbB-2. 2'-Thioadenosine covalently inactivates ErbB-1 via modification of a cysteine residue at the active site[1].

Product Specifications

CAS Number

[136904-69-3]

Product Name Alternative

PD157432

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-thioadenosine.html

Solubility

10 mM in DMSO

Smiles

NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3S)C2=NC=N1

Molecular Formula

C10H13N5O3S

Molecular Weight

283.31

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Singh J, et, al. Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases. J Med Chem. 1997 Mar 28;40 (7) :1130-5.