Indazole-Cl

Indazole-Cl (Ind-Cl) is an Estrogen receptor (ER) -β-specific agonist with inflammatory effect. Indazole-Cl inhibits cyclooxygenase-2 exression reduction induced by hypoxia. And Indazole-Cl inhibits ROS production. Indazole-Cl also inhibits cell migration and invasion by hypoxia increased by hypoxia. Indazole-Cl is potent inhibitor of hypoxia-induced inﬂammation in vascular smooth muscle cells (VSMCs) [1].

Product Specifications

CAS Number

[848142-62-1]

Product Name Alternative

Ind-Cl

UNSPSC

12352005

Hazard Statement

H302

Target

COX; Estrogen Receptor/ERR

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/indazole-cl.html

Purity

98.72

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC1=CC2=C(Cl)N(C3=CC=C(O)C=C3)N=C2C=C1

Molecular Formula

C13H9ClN2O2

Molecular Weight

260.68

Precautions

H302

References & Citations

[1]Park C, et al. Indazole-Cl inhibits hypoxia-induced cyclooxygenase-2 expression in vascular smooth muscle cells. J Mol Endocrinol. 2019 Jul 1;63 (1) :27-38.