Cp028
Cp028 is a potent pre-mRNA splicing inhibitor. cp028 inhibits splicing in HeLa nuclear extract with an IC50 value of 54 µM[1].
Product Specifications
CAS Number
[347397-83-5]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cp028.html
Purity
99.71
Solubility
10 mM in DMSO
Smiles
O=C1NC(/C(C(N1C2=CC=CC=C2CC)=O)=C\C3=CC=C(C4=CC=C(F)C=C4)O3)=O
Molecular Formula
C23H17FN2O4
Molecular Weight
404.39
References & Citations
[1]Sidarovich A, et al. Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. Elife. 2017 Mar 16;6:e23533.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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