6-Mercaptopurine-13C2,15N

6-Mercaptopurine-13C2,15N is the 13C- and 15N-labeled 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive agent.

Product Specifications

CAS Number

[1190008-04-8]

Product Name Alternative

Mercaptopurine-13C2,15N; 6-MP-13C2,15N

UNSPSC

12352005

Target

Autophagy; Endogenous Metabolite; Nucleoside Antimetabolite/Analog

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/6-mercaptopurine-13c2-15n.html

Purity

96.0

Solubility

10 mM in DMSO|DMSO : 35.71mg/mL (ultrasonic)

Smiles

SC1=C2[13C](N[13CH]=[15N]2)=NC=N1

Molecular Formula

C3 13C2H4N3 15NS

Molecular Weight

155.16

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Sahasranaman S, et al. Clinical pharmacology and pharmacogenetics of thiopurines. Eur J Clin Pharmacol. 2008 Aug;64 (8) :753-67.|[3]Liu Q, et al. 6-Mercaptopurine augments glucose transport activity in skeletal muscle cells in part via a mechanism dependent upon orphan nuclear receptor NR4A3. Am J Physiol Endocrinol Metab. 2013 Nov 1;305 (9) :E1081-92.|[4]Kanemitsu H, et al. 6-Mercaptopurine (6-MP) induces cell cycle arrest and apoptosis of neural progenitor cells in the developing fetal rat brain. Neurotoxicol Teratol. 2009 Mar-Apr;31 (2) :104-9.